ABSTRACT Introduction: the onset of minimally invasive surgery, such as laparoscopic surgery, was accompanied by an increased frequency of complications, many of which were life-threatening.With the objective of minimizing morbidity and mortality and accelerating the learning curve, video laparoscopic surgery simulators were developed to improve th

Selective Serotonin Reuptake Inhibitors (SSRIs) are the most popular psychiatric medications that are approved for several neuropsychiatric conditions such as depression and obsessive-compulsive disorder (OCD).On the other hand, clomipramine is a Push Button Switch tricyclic anti-depressant which is the only approved medication, among this class, t

The human brain is able to flexibly adapt its information processing capacity to meet a variety of cognitive challenges.Recent evidence suggests that this flexibility is reflected in the dynamic reorganization of the functional connectome.The ascending catecholaminergic arousal systems of the brain are a plausible candidate mechanism for driving al